Impact of Gender on Outcomes of Transcatheter edge to edge mitral valve repair: A Meta-analysis.

Background: Gender disparities in outcomes after mitral valve surgery are well known. There only few studies reporting the influence of gender on following transcatheter edge to repair (TEER) using MitraClip (MC). In this meta-analysis, we describe by TEER. Methods: Studies specific patients treated with MC were reviewed from January 2010 February 2022. Outcomes evaluated include all-cause mortality, New York Heart Association (NYHA) class, readmission for heart failure and residual regurgitation (MR) at longest follow up. Pooled odds ratio (OR) 95% confidence interval (CI) calculated random effects models. Results: Seventeen 33,747 (19,303 males 14,444 females) included. was no difference mortality (OR: 1.00, CI: [0.90-1.12], p=0.93), MR 0.59, [0.34-1.02], p=0.06) or 1.04, [0.69-1.57], p=0.83). However, NYHA class III/IV more frequent female as compared male end up 0.62, [0.51-0.74], p<0.00001). Conclusions: Our largest date, suggests that have worse NHYA functional TEER without any readmissions when patients.